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Tick-borne encephalitis vaccine is a vaccine used against tick-borne encephalitis (TBE).The vaccine is highly immunogenic with seroconversion rates of over 87%.The first vaccine against TBE was prepared in 1941 in the brains of mice. Some 20 years later TBE vaccines derived from cell cultures (chicken embryo fibroblast cells) were developed and used for active immunization in humans in the former Soviet Union.

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