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Thyroid-stimulating hormone (also known as thyrotropin TSH or hTSH for human TSH) is a hormone that stimulates the thyroid gland to produce thyroxine (T4) and then triiodothyronine (T3) which stimulates the metabolism of almost every tissue in the body. It is a glycoprotein hormone synthesized and secreted by thyrotrope cells in the anterior pituitary gland which regulates the endocrine function of the thyroid gland.

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