Tags: Enzyme.
Thioredoxin reductases (TR TrxR) (EC 1.8.1.9) are the only known enzymes to reduce thioredoxin (Trx). Two classes of thioredoxin reductase have been identified: one class in bacteria and some eukaryotes and one in animals. Both classes are flavoproteins which function as homodimers. Each monomer contains a FAD prosthetic group a NADPH binding domain and an active site containing a redox-active disulfide bond.
