Tags: Chemical Compound, Chemical Substance.
TC-1827 is an orally active selective agonist of the α4β2 nicotinic receptors. Administration of TC-1827 improved memory and learning in a variety in rodents and increased long-term potentiation in hippocampal slices. In addition the compound was without significant cardiovascular side effects except for a small transient rise in arterial blood pressure. The pro-cognitive effects of TC-1827 last much longer than the short half life (0.2 – 1.0 hours) would suggest.
