Tags: Chemical Compound, Chemical Substance.
The TASF reagent or tris(dimethylamino)sulfonium difluorotrimethylsilicate is a reagent in organic chemistry with structural formula [((CH3)2N)3S]+[F2Si(CH3)3]-. It is an anhydrous source of fluoride and is used to cleave silyl ether protective groups. Many other fluoride reagents are known but few are truly anhydrous because of the extraordinary basicity of naked F-. In TASF the fluoride is masked as an adduct with the weak Lewis acid trimethylsilylfluoride (FSi(CH3)3).
