Tags: Protein.
T-box refers to a group of transcription factors involved in limb and heart development.In humans and some other animals defects in the TBX5 gene expression can lead to finger-like thumbs and ventricular septal defects in which there is no separation between the left and right ventricle of the heart and are responsible for Holt-Oram syndrome.TBX3 is associated with ulnar-mammary syndrome.Genes encoding T-box proteins include:
