Tags: Protein.
Sulfatase-modifying factor 1 is an enzyme that in humans is encoded by the SUMF1 gene.Sulfatases catalyze the hydrolysis of sulfate esters such as glycosaminoglycans sulfolipids and steroid sulfates. C-alpha-formylglycine (FGly) the catalytic residue in the active site of eukaryotic sulfatases is posttranslationally generated from a cysteine by SUMF1 the FGly-generating enzyme (FGE) in the endoplasmic reticulum (ER).