Tags: Protein.
START (StAR-related lipid-transfer) is a lipid-binding domain in StAR HD-ZIP and signalling proteins. The archetypical domain is found in StAR (Steroidogenic acute regulatory protein) a mitochondrial protein that is synthesized in steroid-producing cells. StAR and initiates steroid production by mediating the delivery of cholesterol to the first enzyme in steroidogenic pathway. The START domain is critical for this activity perhaps through the binding of cholesterol.
