Tags: Protein.
Protein sprouty homolog 4 is a protein that in humans is encoded by the SPRY4 gene.SPRY4 is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. It is positioned upstream of RAS (see HRAS; MIM 190020) activation and impairs the formation of active GTP-RAS (Leeksma et al. 2002).[supplied by OMIM]