Tags: Protein.
Spartin is a protein that in humans is encoded by the SPG20 gene.This gene encodes a protein that contains a MIT (Microtubule Interacting and Trafficking molecule) domain. This protein may be involved in endosomal trafficking microtubule dynamics or both functions. Frameshift mutations associated with this gene cause autosomal recessive spastic paraplegia 20 (Troyer syndrome).Troyer syndrome (SPG20) is a complicated type of hereditary spastic paraplegias (HSPs).