Tags: Protein.
Msx2-interacting protein is a protein that in humans is encoded by the SPEN gene.This gene encodes a hormone inducible transcriptional repressor. Repression of transcription by this gene product can occur through interactions with other repressors by the recruitment of proteins involved in histone deacetylation or through sequestration of transcriptional activators. The product of this gene contains a carboxy-terminal domain that permits binding to other corepressor proteins.