Sophia of Saxe-Weissenfels (also: Sophie; born: 23 June 1654 in Halle an der Saale died: 31 March 1724 in Zerbst) was a member of the Albertine branch of the House of Wettin and a princess of Saxe-Weissenfels and Querfurt by birth and by marriage Duchess of Anhalt-Zerbst.