Tags: Drug.

Sirolimus (INN/USAN) also known as rapamycin is a macrolide produced by the bacteria Streptomyces hygroscopicus. It has immunosuppressant functions in humans and is used to prevent rejection in organ transplantation; it is especially useful in kidney transplants. It prevents activation of T cells and B cells by inhibiting their response to interleukin-2 (IL-2). Sirolimus is also used as a coronary stent coating.

Sirolimus.svg
ATC prefix
L04
ATC suffix
AA10
Bioavailability
20.0
CAS number
53123-88-9
ChEBI
9168
DrugBank
DB00877
FDA UNII code
W36ZG6FT64
IUPAC name
hexamethyl-2327-epoxy-3H-pyrido[21-c][14]-, oxaazacyclohentriacontine-15112829, (3S6R7E9R10R12R14S15E17E19E21S23S, (4H6H31H)-pentone, [(1R)-2-[(1S3R4R)-4-hydroxy-3-methoxycyclohexyl]-, 1-methylethyl]-1021-dimethoxy-6812142026-, 26R27R34aS)-910121314212223242526, 2732333434a-hexadecahydro-927-dihydroxy-3-
PubChem
5284616

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