Tags: Drug.
Siramesine (or Lu 28-179) is a sigma receptor agonist selective for the σ2 subtype. In animal studies siramesine has been shown to produce anxiolytic and antidepressant effects. It was developed by the pharmaceutical company H Lundbeck for the treatment of anxiety although development was discontinued after clinical trials showed a lack of efficacy in humans.Siramesine has been shown to produced an enhanced antidepressant effect when co-administered with NMDA antagonists.
