Tags: Drug.
Siltuximab (INN) (also known as Sylvant CNTO 328 Anti-IL-6 chimeric monoclonal antibody or cCLB8) is a chimeric (made from human and mouse proteins) monoclonal antibody. It binds to interleukin-6. Siltuximab has been investigated for the treatment of metastatic renal cell cancer prostate cancer and Castleman’s disease among other types of cancer.It has undergone a phase I clinical trial in patients With B-cell non-Hodgkin’s lymphoma multiple myeloma or Castleman’s disease.