Tags: Protein.
SH3 domain-containing kinase-binding protein 1 is an enzyme that in humans is encoded by the SH3KBP1 gene.CBL (MIM 165360) constitutively interacts with SH3 domain-containing proteins and upon tyrosine phosphorylation with SH2 domain-containing proteins. The SH3KBP1 gene encodes an 85-kD CBL-interacting protein that enhances tumor necrosis factor (MIM 191160)-mediated apoptotic cell death (Narita et al. 2001).[supplied by OMIM]