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In medicine sclerosis (also spelled sclerosus in the names of a few disorders; from Greek σκληρός hard) refers to the stiffening of a structure usually caused by a replacement of the normal organ-specific tissue with connective tissue.Types include:Amyotrophic lateral sclerosis sometimes known as motor neuron disease or Lou Gehrig’s disease a progressive incurable usually fatal disease of motor neurons.Atherosclerosis a deposit of fatty materials such as cholesterol in the arteries which causes hardening.Focal segmental glomerulosclerosis is a disease that attacks the kidney’s filtering system (glomeruli) causing serious scarring and thus a cause of nephrotic syndrome in children and adolescents as well as an important cause of kidney failure in adults.Hippocampal sclerosis a brain damage often seen in individuals with temporal lobe epilepsy.Lichen sclerosus a disease that hardens the connective tissues of the vagina of women and the penis of men.

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