Tags: Chemical Compound, Chemical Substance.

S-Adenosyl methionine (SAM-e SAMe SAM AdoMet ademetionine) is a common cosubstrate involved in methyl group transfers. SAM was first discovered in Italy by G. L. Cantoni in 1952. It is made from adenosine triphosphate (ATP) and methionine by methionine adenosyltransferase (EC 2.5.1.6). Transmethylation transsulfuration and aminopropylation are the metabolic pathways that use SAM.

S-Adenosyl_methionine.png
IUPAC name
(2S)-2-Amino-4-(2S3S4R5R)-5-(6-aminopurin-9-yl)-34-dihydroxyoxolan-2-yl]methyl-methylsulfonio]butanoate

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