Tags: Drug.
RWJ-394674 is a drug that is used in scientific research. It is a potent orally active analgesic drug that produces little respiratory depression. RWJ-394674 itself is a potent and selective agonist for δ-opioid receptors with a Ki of 0.24 nM at δ and 72 nM at μ. However once inside the body RWJ-394674 is dealkylated to its monodesethyl metabolite RWJ-413216 which is a potent agonist at the μ-opioid receptor and has less affinity for δ (Ki 0.26 nM at μ 46.7 nM at δ).
