Tags: Drug.

3β-(4-methylphenyl)-2β-[3-(4-chlorophenyl)isoxazol-5-yl]tropane (RTI-371) is a phenyltropane derived drug which acts as a potent and selective dopamine reuptake inhibitor in vitro yet unusually for this class of compound both RTI-371 and the closely related compound RTI-370 failed to produce locomotor stimulation in mice. In addition to this in drug substitution tests RTI-370 weakly generalized to cocaine whereas RTI-371 did not generalize at all.

RTI-371_structure.png
CAS number
652978-45-5
IUPAC name
3-(4-chlorophenyl)-5-[(1R2S3S5S)-8-methyl-3-(4-methylphenyl)-8-azabicyclo[3.2.1]octan-2-yl]-12-oxazole
PubChem
11474847

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