Rottlerin is a potent large conductance potassium channel (BKCa++) opener. BKCa++ is found in the inner mitochondrial membrane of cardiomyocytes. Opening these channels is beneficial for post-ischemic changes in vasodilation. Other BKCa++ channel openers are reported to limit the mitochondrial calcium overload due to ischemia. Rottlerin is also capable of reducing oxygen radical formation.
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