Tags: Drug.
ROD-188 is a sedative drug that was structurally derived from the GABAA antagonist bicuculline by a team at Roche. Unlike bicuculline ROD-188 acts as an agonist at GABAA receptors being a positive allosteric modulator acting at a novel binding site distinct from those of benzodiazepines barbiturates or muscimol with its strongest effect produced at the α6β2γ2 subtype of the GABAA receptor.
