Tags: Drug.

RO-4491533 is a drug developed by Hoffmann-La Roche which acts as a potent and selective negative allosteric modulator for group II of the metabotropic glutamate receptors (mGluR2/3) being equipotent at mGluR2 and mGluR3 but without activity at other mGluR subtypes. In animal studies RO-4491533 produced antidepressant effects and reversed the effects of the mGluR2/3 agonist LY-379268 with similar efficacy but slightly lower potency than the mGluR2/3 antagonist LY-341495.

RO4491533_structure.png
ATC prefix
None
CAS number
579482-31-8
IUPAC name
4-[3-(26-dimethylpyridin-4-yl)phenyl]-7-methyl-8-trifluoromethyl-13-dihydrobenzo[b][14]diazepin-2-one
PubChem
11158623

Loading...

This page contains content from the copyrighted Wikipedia article "RO4491533"; that content is used under the GNU Free Documentation License (GFDL). You may redistribute it, verbatim or modified, providing that you comply with the terms of the GFDL.