Tags: Protein.
RNase PH is a 3′-5′ exoribonuclease and nucleotidyltransferase present in archaea and bacteria that is involved in tRNA processing. Contrary to hydrolytic enzymes it is a phosphorolytic enzyme meaning that it uses inorganic phosphate as a cofactor to cleave nucleotide-nucleotide bonds releasing diphosphate nucleotides. The active structure of the proteins is actually a homohexameric complex consisting of three ribonuclease (RNase) PH dimers.
