Tags: Drug.
Rilonacept also known as IL-1 Trap (marketed by Regeneron Pharmaceuticals under the trade name Arcalyst) is an interleukin 1 inhibitor.Rilonacept is a dimeric fusion protein consisting of the ligand-binding domains of the extracellular portions of the human interleukin-1 receptor component (IL-1R1) and IL-1 receptor accessory protein (IL-1RAcP) linked in-line to the fragment-crystallizable portion (Fc region) of human IgG1 that binds and neutralizes IL-1.Rilonacept was given an Orphan Drug status by the United States Food and Drug Administration and is used for the treatment of cryopyrin-associated periodic syndromes (CAPS) including familial cold autoinflammatory syndrome Muckle-Wells syndrome and neonatal onset multisystem inflammatory disease(not approved in the U.S.