Tags: Protein.
RIG-I (retinoic acid-inducible gene 1) is a RIG-I-like receptor dsRNA helicase enzyme that is encoded (in humans) by the DDX58 gene. RIG-I is part of the RIG-I-like receptor (RLR) family which also includes MDA5 and LGP2 and functions as a pattern recognition receptor that is a sensor for viruses. RIG-I typically recognizes short (< 4000nt) 5′ triphosphate dsRNA. RIG-I and MDA5 are involved in activating MAVS and triggering an antiviral response.