Tags: Protein.
A ribosome-inactivating protein is a protein synthesis inhibitor that acts at the ribosome.A number of bacterial and plant toxins act by inhibiting protein synthesis in eukaryotic cells. The toxins of the Shiga and ricin family inactivate 60S ribosomal subunits by an N-glycosidic cleavage which releases a specific adenine base from the sugar-phosphate backbone of 28S rRNA. Members of the family include shiga and shiga-like toxins and type I (e.g. trichosanthin and luffin) and type II (e.g.
