Tags: Disease.

Reticular pigmented anomaly of the flexures (also known as Dark dot disease and Dowling–Degos’ disease) is a fibrous anomaly of the flexures or bending parts of the axillae neck and inframammary/sternal areas. It is an autosomal-dominant pigmentary disorder that may appear in adolescence or adulthood. This condition is due to mutations in structural/desmosomal proteins found within stratified squamous epithelium.Dark dot disease is associated with KRT5.

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