Receptor activity-modifying proteins (RAMPs) are a class of protein that interact with and modulate the activities of several Class B G Protein-Coupled Receptors including the receptors for secretin calcitonin (CT) glucagon and vasoactive intestinal peptide (VIP). There are three distinct types of RAMPs designated RAMP1 RAMP2 and RAMP3 each encoded by a separate gene.