Tags: Protein.
RAS guanyl-releasing protein 2 is a protein that in humans is encoded by the RASGRP2 gene.The protein encoded by this gene is a brain-enriched nucleotide exchanged factor that contains an N-terminal GEF domain 2 tandem repeats of EF-hand calcium-binding motifs and a C-terminal diacylglycerol/phorbol ester-binding domain. This protein can activate small GTPases including RAS and RAP1/RAS3. The nucleotide exchange activity of this protein can be stimulated by calcium and diacylglycerol.