Tags: Protein.
Ran GTPase-activating protein 1 is an enzyme that in humans is encoded by the RANGAP1 gene.RanGAP1 is a homodimeric 65-kD polypeptide that specifically induces the GTPase activity of RAN but not of RAS by over 1000-fold. RanGAP1 is the immediate antagonist of RCC1 a regulator molecule that keeps RAN in the active GTP-bound state. The RANGAP1 gene encodes a 587-amino acid polypeptide.