Tags: Protein.
RF(Arg-Phe)amide family 26 amino acid peptide also known as P518 is a human protein.The 26-amino acid RF-amide peptide P518 functions as a high-affinity ligand of GPR103. Both GPR103 and P518 precursor mRNA exhibited highest expression in brain. The 43-amino acid QRFP peptide a longer form of the P518 peptide is necessary to exhibit full agonistic activity with GPR103. Intravenous administration QRFP caused release of aldosterone suggesting that QRFP and GPR103 regulate adrenal function.