Tags: Disease.
Pyruvate carboxylase deficiency is an inherited disorder that causes lactic acid and other potentially toxic compounds to accumulate in the blood. High levels of these substances can damage the body’s organs and tissues particularly in the nervous system. Pyruvate carboxylase deficiency is a rare condition with an estimated incidence of 1 in 250000 births worldwide. This disorder appears to be much more common in some Algonkian Indian tribes in eastern Canada.[citation needed]
