Tags: Enzyme.
Pyrrolysine—tRNAPyl ligase (EC 6.1.1.26 PylS pyrrolysyl-tRNA synthetase) is an enzyme with system name L-pyrrolysine:tRNAPyl ligase (AMP-forming). This enzyme catalyses the following chemical reaction ATP + L-pyrrolysine + tRNAPyl AMP + diphosphate + L-pyrrolysyl-tRNAPylThis enzyme is specific for pyrrolysine as substrate as it cannot be replaced by lysine or any of the other natural amino acids.