Tags: Protein.
Presenilin-1 (PS-1) is a protein that in humans is encoded by the PSEN1 gene. Presenilin 1 is one of the four core proteins in presenilin complex which mediate the regulated proteolytic events of several proteins in the cell including gamma secretase. Gamma-secretase is considered to play a very important role in generation of beta amyloid accumulation of which is related to the onset of Alzheimer’s Disease from the beta-amyloid precursor protein.