Tags: Drug.
PSB-10 is a drug which acts as a selective antagonist for the adenosine A3 receptor (ki value at human A3 receptor is 0.44 nM) with high selectivity over the other three adenosine receptor subtypes (ki values at human A1 A2A and A2B receptors are 4.1 3.3 and 30 µM). Further pharmacological experiments in a [35S]GTPγS binding assay using hA3-CHO-cells indicated that PSB-10 acts as an inverse agonist (IC50 = 4 nM). It has been shown to produce antiinflammatory effects in animal studies.
