Tags: Drug.
Proglumide (Milid) is a drug that inhibits gastrointestinal motility and reduces gastric secretions. It acts as a cholecystokinin antagonist which blocks both the CCKA and CCKB subtypes. It was used mainly in the treatment of stomach ulcers although it has now been largely replaced by newer drugs for this application.An interesting side effect of proglumide is that it enhances the analgesia produced by opioid drugs and can prevent or even reverse the development of tolerance to opioid drugs.
