Tags: Protein.
Melanoma antigen preferentially expressed in tumors is a protein that in humans is encoded by the PRAME gene.This gene encodes an antigen that is predominantly expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues except testis. This expression pattern is similar to that of other CT antigens such as MAGE BAGE and GAGE. However unlike these other CT antigens this gene is also expressed in acute leukemias.