Tags: Chemical Compound, Chemical Substance.
PP2 is a substance that has frequently been used in cancer research as a selective inhibitor for Src-family kinases. It strongly inhibits the kinases Lck (IC50=4 nM) Fyn (5 nM) and Hck (5 nM) shows weaker inhibition of EGFR (480 nM) and practically no inhibition of ZAP-70 (100 µM) and JAK2 (50 µM). Despite its extensive use as a Src-selective inhibitor recent research has shown that PP2 is non-selective and inhibits many other kinases with similar affinities.
