Polymyxin B

Tags: Drug.

Polymyxin B is an antibiotic primarily used for resistant Gram-negative infections. It is derived from the bacterium Bacillus polymyxa. Polymyxin B is composed of a number of related compounds (see Mixture Composition). It has a bactericidal action against almost all Gram-negative bacilli except the Proteus and Neisseria genera. Polymyxins bind to the cell membrane and alter its structure making it more permeable. The resulting water uptake leads to cell death.

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ATC prefix

A07

ATC suffix

AA05

CAS number

1405-20-5

DrugBank

DB00781

IUPAC name

N-[4-amino-1-[[1-[[4-amino-1-oxo-1-[[6918-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-(2-methylpropyl)-25811141720-heptaoxo-14710131619-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]-6-methyloctanamide

PubChem

5702105