Tags: Chemical Compound, Chemical Substance.

Plinabulin (NPI-2358) is an experimental cancer drug. It is a synthetic analog of the natural compound phenylahistin. Plinabulin interrupts tumor blood flow via disruption of the tumor’s vascular endothelial cells resulting in tumor necrosis. It also has a tubulin-depolymerizing activity.It has undergone Phase I and Phase II clinical trials for non-small cell lung cancer.

Plinabulin.svg
IUPAC name
(3Z6Z)-3-Benzylidene-6-[5-(2-methyl-2-propanyl)-1H-imidazol-4-yl]methylene-25-piperazinedione

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