Platelet-derived growth factor receptors (PDGF-R) are cell surface tyrosine kinase receptors for members of the platelet-derived growth factor (PDGF) family. PDGF subunits -A and -B are important factors regulating cell proliferation cellular differentiation cell growth development and many diseases including cancer. There are two forms of the PDGF-R alpha and beta each encoded by a different gene. Depending on which growth factor is bound PDGF-R homo- or heterodimerizes.
