Tags: Drug.
Piperoxan also known as benodaine is a drug which was the very first antihistamine to be discovered. This compound derived from benzodioxan was prepared in the early 1930s by Daniel Bovet and Ernest Fourneau at the Pasteur Institute in France. Formerly investigated by Fourneau as an α-adrenergic-blocking agent they demonstrated that it also antagonized histamine-induced bronchospasm in guinea pigs and published their findings in 1933.
