Tags: Protein.
Piezo1 is a mechanosensitive ion channel protein that in humans is encoded by the gene PIEZO1. Piezo1 and its close homolog piezo2 were cloned in 2010 using an siRNA-based screen for mechanosensitive ion channels. Piezo1 and piezo2 share 47% identity with each other and they have no similarity to any other protein and contain no known protein domains. They are predicted to have 24-36 transmembrane domains depending on the prediction algorithm used.