Tags: Protein.
E3 SUMO-protein ligase PIAS3 is an enzyme that in humans is encoded by the PIAS3 gene.PIAS proteins were originally identified in studies that were aimed to decipher the Janus Kinase (JAK)/STAT signaling pathway. The mammalian PIAS family consists of four members: PIAS1 PIAS2 PIAS3 and PIAS4. In Drosophila a single PIAS homologue named dPIAS/Zimp has been identified. In yeast two PIAS-related proteins were identified namely SIZ1 and SIZ2.