Tags: Enzyme.
Phosphatidylethanolamine N-methyltransferase (abbreviated PEMT also lipid methyl transferase LMTase phosphatidylethanolamine methyltransferase phosphatidylethanolamine-N-methylase phosphatidylethanolamine-S-adenosylmethionine methyltransferase) is an enzyme (EC 2.1.1.17) of the transferase class which catalyzes the conversion of phosphatidylethanolamine (PE) to phosphatidylcholine (PC) in the liver via three sequential methylations by S-adenosyl methionine (SAM).While the CDP-choline pathway in which choline obtained either by dietary consumption or by metabolism of choline-containing lipids is converted to PC accounts for approximately 70% of PC biosynthesis in the liver the PEMT pathway has been shown to have played a critical evolutionary role in providing PC during times of starvation.
