Pho4 is a basic helix-loop-helix (bHLH) transcription factor found in S. cerevisiae and other yeasts.The Pho4 homodimer binds to DNA sequences containing the bHLH binding site 5′-CACGTG-3′. This sequence is found in the promoters of genes upregulated in response to phosphate availability such as the PHO5 gene.
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