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Phenylethanolamine N-methyltransferase (PNMT) is an enzyme found in the adrenal medulla that converts norepinephrine (noradrenaline) to epinephrine (adrenaline).PNMT is positively influenced by cortisol which is produced in the adrenal cortex.S-adenosyl-L-methionine (SAM) is a required cofactor. PNMT catalyzes the transfer of a methyl group from SAM to norepinephrine converting it into epinephrine. This enzyme also converts phenethylamine to N-methylphenethylamine an isomer of amphetamine.

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