Tags: Protein.
The PHD finger (Plant Homeo Domain) was discovered in 1993 as a Cys4-His-Cys3 motif in the homeodomain protein HAT3 in Arabidopsis thaliana. The PHD finger motif resembles the metal binding RING domain (Cys3-His-Cys4) and FYVE domain. It occurs as a single finger but often in clusters of two or three and it also occurs together with other domains such as the chromodomain and the bromodomain.