Tags: Protein.
Progesterone receptor membrane component 1 (abbreviated PGRMC1) is a protein which co-purifies with progesterone binding proteins in the liver and ovary. In humans the PGRMC1 protein is encoded by the PGRMC1 gene. The Sigma-2 receptor was recently identified as PGRMC1.The sole biochemical function of PGRMC1 is heme-binding. PGRMC1 shares key structural motifs with cytochrome b5. PGRMC1 binds and activates P450 proteins which are important in drug hormone and lipid metabolism.